Simulation and prediction tool for paediatric clinicians. Digital repository solution storing paediatric clinical data for millions of young patients, enabling physicians to make more informed decisions. Using MD-Paedigree, doctors can select a highly individualised treatment option and receive on-the-spot support in predicting the likely outcome of such treatments based on each patient’s personal medical data. It provides three fundamental functionalities on top of those of an advanced Electronic Health Records registry: 1. similarity search, allowing clinicians to access “patients like mine” (and finding decision support for optimal treatment also based on comparative outcome analysis), and allowing patients to get in touch with “patients exactly like me”. 2. model-based patient-specific simulation and prediction. 3. patient-specific clinical workflows.